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Acetylcholine Receptor (AChR) Antibodies  (ACETYL)

Synonyms:  ACRAB; Myasthenia gravis antibody
Specimen:  Blood; (1) SST (serum separator tube) or Red (no preservative) top tube. No isotopes should be administered to patient 24 hours prior to venipuncture.
                        Volume:  Full primary tube
Minimum Volume:  0.3 mL serum (this amount does not allow for repeat testing).
Collection:  If tube other than an SST is collected, transfer serum or plasma to a tightly capped plastic aliquot tube within 2 hours of collection for transport. Refrigerate at 2-8°C.
Storage:  Refrigerate at 2-8 degrees C
Rejection Criteria:  Excessive hemolysis; chylous serum; recently administered isotopes; improper labeling.
Reference Range:  Negataive: 0-024nmol/L lBorderline: 0.25 - 0.40 nmol/L Positive: >0.40 nmo1/l
Methodology:  This assay measures antibodies that precipitate solublized muscle AChR that has been complexed with radiolabeled alpha-bungarotoxin (aBTX). Antibodies that bind to the receptor regions that are not sterically blocked by the aBTX are detected.
Test Use:  In vitro diagnostic semiquantitative determination of autoantibodies against the acetylcholine receptor in human serum and plasma. This assay is the primary test for confirming the diagnosis of acquired myasthenia gravis.1
Additional Information:  This assay measures antibodies that precipitate solublized muscle AChR that has been complexed with radiolabeled alpha-bungarotoxin (aBTX). Antibodies that bind to the receptor regions that are not sterically blocked by the aBTX are detected.
Testing Includes:  Specimen sent to LabCorp. LabCorp test # 085902.
Testing Facility:  LabCorp