Acetylcholine Receptor (AChR) Antibodies (ACETYL)
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| Synonyms:
| ACRAB; Myasthenia gravis antibody |
| Specimen: | Blood; (1) SST (serum separator tube) or Red (no preservative) top tube.
No isotopes should be administered to patient 24 hours prior to venipuncture.
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| Volume: | Full primary tube |
| Minimum Volume: | 0.3 mL serum (this amount does not allow for repeat testing). |
| Collection: | If tube other than an SST is collected, transfer serum or plasma to a tightly capped plastic aliquot tube within 2 hours of collection for transport.
Refrigerate at 2-8°C. |
| Rejection Criteria: | Excessive hemolysis; chylous serum; recently administered isotopes; improper labeling. |
| Reference Range: | Negataive: 0-024nmol/L lBorderline: 0.25 - 0.40 nmol/L Positive: >0.40 nmo1/l |
| Methodology: | This assay measures antibodies that precipitate solublized muscle AChR that has been complexed with radiolabeled alpha-bungarotoxin (aBTX). Antibodies that bind to the receptor regions that are not sterically blocked by the aBTX are detected. |
| Test Use: | In vitro diagnostic semiquantitative determination of autoantibodies against the acetylcholine receptor in human serum and plasma. This assay is the primary test for confirming the diagnosis of acquired myasthenia gravis.1
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| Additional Information: | This assay measures antibodies that precipitate solublized muscle AChR that has been complexed with radiolabeled alpha-bungarotoxin (aBTX). Antibodies that bind to the receptor regions that are not sterically blocked by the aBTX are detected.
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| Testing Includes: | Specimen sent to LabCorp. LabCorp test # 085902. |
| Testing Facility: | LabCorp |