Leukocyte Alkaline Phosphatase (LAP)
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| Synonyms:
| LAP |
| Specimen: | Smears made from heparinized specimen or fingerstick. Green (heparin) top vacutainer tube; slides must be made within 24 hours of collection.
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| Volume: | Full primary tube to make 6 blood smears |
| Minimum Volume: | |
| Collection: | Slides must be made within 24 hours of collection.
Maintain slides at room temperature up to 7 days. |
| Rejection Criteria: | Heparin tube specimen more than 24 hours old; frozen slides; slides more than seven days old; slides made from any anticoagulant other than heparin; improper labeling. |
| Reference Range: | 25-130 |
| Methodology: | Enzyme Reaction. |
| Test Use: | Differentiation of chronic myelocytic leukemia from leukemoid reaction |
| Additional Information: | Low scores have been associated with CML, PNH, thrombocytopenic purpura and hereditary hypophosphatasia. In non-leukemic neutrophilia, the LAP rises as the WBC rises. |
| Testing Includes: | Specimen sent to LabCorp. LabCorp test # 001966.
LAP score determined for 100 neutrophilic leukocytes. |
| Testing Facility: | LabCorp |